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Die angehende FBI-Agentin Clarice Starling (J. Foster) bekommt einen Spezialauftrag: Mit Hilfe des brillanten Psychiaters Hannibal Lecter (A. Hopkins) soll sie versuchen, einen Serienkiller zu fassen. Die Zeit drängt, denn "Buffalo Bill" hat bereits ein neues Opfer in seiner Gewalt. Was das Team Starling/Lecter zu einem besonderen macht: Lecter ist selbst verurteilter Mörder mit kannibalischen Neigungen.