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Als das tödliche "Reaper"-Virus in Schottland Hunderttausende in den Tod reißt, errichtet die britische Regierung kurzerhand eine unüberwindliche Mauer. 30 Jahre später hat die Welt die zerstörte Region vergessen. Als die Seuche mitten in London erneut ausbricht, soll die taffe Eden Sinclair (Rhona Mitra) mit einem Elite-Team in die Sperrzone eindringen und Dr. Kane (Malcolm McDowell) finden, der ein Gegenmittel kennt. Der völlig übergeschnappte Bandenanführer Sol (Craig Conway) versucht dies mit allen Mitteln zu verhindern.
