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Während eines gemeinsamen Besuchs im pakistanischen Karatchi 2002 verabschiedet sich der Wall Street Journal-Korrespondent Daniel Pearl (Dan Futterman) von seiner hochschwangeren Frau Mariane (Angelina Jolie), einer investigativen Journalistin, um sich mit einem seiner Kontaktleute zu treffen. Doch ihm wird beim Versuch, Hintergründe über ein Flugzeugattentat aufzudecken, eine Falle gestellt und er gerät in die Klauen von Terroristen. Diese Geschehnisse wird seine Frau später in einem Buch verarbeiten...
