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Der unbarmherzige Verbrecherboss Frank Lucas (Denzel Washington) beherrscht die skrupellose Drogen-Unterwelt von Harlem mit einem striktem Ehrenkodex und gerissener Machttaktik. Mit unverschnittenem Heroin zu konkurrenzlosen Billigpreisen sticht Lucas nach und nach alle Rivalen aus, bis er sogar über der Mafia steht. Als sich der Underdog-Cop Richie Roberts (Russell Crowe) daran macht, Lucas' Multi-Millionen-Imperium zum Einsturz zu bringen, beginnt für beide Männer ein schicksalhafter Zweikampf auf Leben und Tod ...
